| Player | # | Pos | Ht | Wt | Age | College |
|---|---|---|---|---|---|---|
| Terron Armistead | #72 | LT | 6′ 5″ | 304 | 23 | Arkansas-Pine Bluff |
| Edwin Baker | #27 | RB | 5′ 8″ | 204 | 23 | Michigan State |
| *Marcus Ball | #36 | S | 6′ 1″ | 209 | 27 | Memphis |
| Drew Brees+ | #9 | QB | 6′ 0″ | 209 | 35 | Purdue |
| Brodrick Bunkley | #77 | NT | 6′ 2″ | 306 | 31 | Florida St |
| Rafael Bush | #25 | FS | 5′ 11″ | 203 | 27 | South Carolina St |
| Jarius Byrd | #31 | S | 6′ 0″ | 205 | 28 | Oregon |
| Travis Cadet | #39 | RB | 6′ 1″ | 210 | 25 | Appalachian St |
| Marques Colston | #12 | WR | 6′ 4″ | 225 | 31 | Hofstra |
|
*Brandon Cooks
|
#10 | WR | 5′ 10″ | 183 | 21 | Oregon State |
| *Todd Davis | #52 | LB | 6′ 1″ | 230 | 22 | Sacramento State |
| Brandon Deadrick | #95 | DT | 6′ 4″ | 297 | 27 | Alabama |
| *Brian Dixon | #20 | CB | 6′ 0″ | 195 | 24 | NW Missouri St |
| Jusitn Dresher | #47 | LS | 6′ 1″ | 230 | 26 | Colorado |
| *Kasim Edebali | #91 | OLB | 6′ 2″ | 253 | 25 | Boston College |
| Jahri Evans+ | #73 | RG | 6′ 4″ | 318 | 31 | Bloomburg |
| Moise Fokou | #52 | LB | 6′ 1″ | 228 | 29 | Maryland |
| Glenn Foster | #74 | DE | 6′ 4″ | 285 | 24 | Illinois |
| Jerry Franklin | $59 | LB | 6′ 2″ | 242 | 26 | Arkansas |
|
Terrence Frederick
|
#31 | CB | 5′ 10″ | 187 | 24 | Texas A&M |
| Junior Galette | #93 | LOLB | 6′ 2″ | 258 | 26 | Stillman |
| Jonathon Goodwin | #55 | C | 6′ 3″ | 318 | 36 | Ohio, Michigan |
| Jimmy Graham+ | #80 | TE | 6′ 7″ | 265 | 28 | Miami(Fla) |
| Shayne Graham | #3 | K | 6′ 0″ | 210 | 37 | Virginia Tech |
|
Ryan Griffin
|
#4 | QB | 6′ 5″ | 206 | 24 | Tulane |
| Ben Grubbs | #66 | LG | 6′ 3″ | 310 | 30 | Auburn |
| Parys Haralson | #58 | ROLB | 6′ 0′ | 255 | 30 | Tenneesse |
| Bryce Harris | #79 | T | 6′ 6″ | 300 | 25 | Fresno St |
| David Hawthorne | #57 | LILB | 6′ 0″ | 230 | 29 | TCU |
| Akiem Hicks | #76 | LDE | 6′ 4″ | 352 | 25 | Regina |
| Josh Hill | #89 | TE | 6′ 5″ | 229 | 24 | Idaho St |
| Ramon Humbar | #53 | LILB | 5′ 11″ | 232 | 27 | North Dakota St. |
| Mark Ingram+ | #22 | RB | 5′ 9″ | 215 | 25 | Alabama |
| *Stanley Jean-Baptiste | #33 | CB | 6′ 3″ | 216 | 24 | Nebraska |
| John Jenkins | #92 | DT | 6′ 3″ | 327 | 25 | Georgia |
| Austin Johnson | #35 | RB | 6′ 2″ | 240 | 25 | Tennessee |
| Cameron Jordan | #94 | RDE | 6′ 4″ | 287 | 25 | California |
| Senio Kelemete | #65 | OG | 6” 3″ | 301 | 24 | Washington |
| Kyle Knox | #58 | LB | 6′ 1″ | 220 | 25 | Fresno State |
| Tim Lelito | #68 | G | 6′ 4″ | 335 | 25 | Grand Valley St |
| Brian Leonard | #40 | RB | 6′ 2″ | 226 | 30 | Rutgers |
| Keenan Lewis | #28 | LCB | 6′ 1″ | 207 | 28 | Oregon St |
| Curtis Lofton | #50 | RILB | 6′ 2″ | 238 | 28 | Oklahoma |
| Erik Lorig | #41 | FB | 6′ 4″ | 265 | 28 | Stanford |
| Luke McCown | #7 | QB | 6″ 4″ | 217 | 33 | Louisiana Tech |
| Robert Mechem | #17 | WR | 6′ 2″ | 214 | 30 | Tennessee |
| Joe Morgan | #13 | WR | 6′ 1″ | 184 | 26 | Walsh |
| Thomas Morstead | #6 | P | 6′ 4″ | 225 | 28 | Southern Methodist |
| Eric Olsen | #69 | G | 6′ 3″ | 301 | 26 | Notre Dame |
| Tauren Poole | #27 | RB | 5′ 10″ | 209 | 25 | Tennessee |
| *Ronald Powell | #56 | LB | 6′ 3″ | 237 | 23 | Florida |
| Khiry Robinson | #29 | RB | 6′ 0″ | 220 | 25 | West Texas A&M |
| Patrick Robinson | #21 | CB | 5′ 11″ | 191 | 27 | Florida St. |
| Jamarca Sanford | #38 | FS | 5′ 10″ | 200 | 29 | Mississippi |
| *Jalen Saunders | #18 | WR | 5′ 9″ | 165 | 22 | Oklahoma |
| Kenny Stills | #84 | WR | 6′ 0″ | 190 | 22 | Oklahoma |
| Zach Strief | #64 | RT | 6′ 7″ | 320 | 31 | Northwestern |
| *Vinnie Sunseri | #43 | SS | 5′ 11 | 210 | 23 | Alabama |
| Andy Tanner | #14 | WR | 6′ 0″ | 183 | 26 | Midwestern St |
| Pierre Thomas | #23 | RB | 5′ 11″ | 215 | 30 | Illinois |
| Nick Toon | #88 | WR | 6′ 4″ | 218 | 26 | Wisconsin |
| Kenny Vaccaro | #32 | S | 6′ 0″ | 214 | 23 | Texas |
| *Lawerence Virgil | #62 | NT | 6′ 5″ | 290 | 23 | Valdosta State |
| Tyrunn Walker | #75 | DT | 6′ 3″ | 294 | 24 | Tulsa |
| *Pierre Warren | #42 | FS | 6′ 2 | 200 | 22 | Jacksonville St |
| Ben Watson | #82 | TE | 6′ 3″ | 255 | 34 | Georgia |
| Corey White | #24 | RCB | 5′ 11″ | 206 | 24 | Samford |
- * – Rookie
- + – Pro Bowl Selection
