| Player | # | Pos | Ht | Wt | Age | College |
|---|---|---|---|---|---|---|
| Rashaun Allen | 88 | TE | 6′ 5″ | 250 | 25 | Southern |
| James Anderson | 42 | LB | 6′ 3″ | 220 | 32 | Virginia Tech |
| *Stephone Anthony | 50 | ILB | 6′ 2″ | 245 | 23 | Clemson |
| Terron Armistead | #72 | T | 6′ 5″ | 306 | 25 | Arkansas-Pine Bluff |
| *Tavaris Barnes | #90 | DE | 6′ 4″ | 275 | 23 | Clemson |
| *Delvin Breaux | #40 | CB | 6′ 1″ | 196 | LSU | |
| Drew Brees | #9 | QB | 6′ 0″ | 209 | 36 | Purdue |
| *Austin Brown | # | DT | 6′ 2″ | 295 | 24 | Miami (Ohio) |
| Brandon Browner | #39 | CB | 6′ 4″ | 221 | 31 | Oregon State |
| Rafeal Bush | #25 | S | 5′ 11″ | 180 | 28 | South Carolina St |
| Jarius Byrd | #31 | S | 6′ 0″ | 205 | 28 | Oregon |
| Travis Cadet | #38 | RB | 6′ 1″ | 210 | 26 | Appalachian St |
| Brandin Coleman | #16 | WR | 6′ 6″ | 225 | 23 | Rutgers |
| Marques Colston | #12 | WR | 6′ 4″ | 225 | 32 | Hofstra |
Brandon Cooks | #10 | WR | 5′ 10″ | 189 | 23 | Oregon State |
| *Tyeler Davison | #95 | DT | 6′ 2″ | 315 | 23 | Fresno State |
| Brian Dixon | #20 | CB | 6′ 0″ | 195 | 25 | NW Missouri St |
| Justin Dresher | #47 | LS | 6′ 1″ | 230 | 27 | Colorado |
| Kasim Edebali | #91 | OLB | 6′ 2″ | 253 | 26 | Boston College |
| Dannell Ellerbe | #59 | LB | 6′ 1″ | 236 | 29 | Georgia |
| *Kaleb Eulls | #71 | DT | 6′ 4″ | 285 | 24 | Mississippi State |
| Jahri Evans | #73 | G | 6′ 4″ | 318 | 32 | Bloomberg |
| Matt Flynn | #3 | QB | 6′ 2″ | 228 | 30 | LSU |
| Kai Forbath | #5 | K | 5′ 11″ | 191 | 28 | UCLA |
| *Garrett Grayson | #18 | QB | 6′ 2″ | 215 | 24 | Colorado State |
*Obum Gwacham | #58 | DE | 6′ 5″ | 231 | 24 | Oregon State |
| David Hawthorne | #57 | LB | 6′ 0″ | 230 | 30 | TCU |
| Tim Hightower | #34 | RB | 6′ 0″ | 226 | 29 | Richmond |
| Josh Hill | #89 | TE | 6′ 5″ | 229 | 25 | Idaho St |
| Tony Hills | #76 | T | 6′ 5″ | 305 | 30 | Texas |
| Micheal Hoomanawanui | #84 | TE | 6′ 3″ | 271 | 27 | Illinois |
| Ramon Humbar | #54 | LB | 5′ 11″ | 232 | 28 | North Dakato St. |
| Kendall Hunter | #48 | RB | 5′ 7″ | 199 | 27 | Oklahoma State |
| Mark Ingram | #28 | RB | 5′ 9″ | 215 | 25 | Alabama |
| John Jenkins | #92 | DT | 6′ 4″ | 359 | 26 | Georgia |
| Austin Johnson | #35 | RB | 6′ 2″ | 240 | 26 | Tennessee |
| Seantavius Jones | #15 | WR | 6′ 3″ | 200 | 23 | Valdosta State |
| Cameron Jordan+ | #94 | DE | 6′ 3″ | 287 | 26 | California |
| Senio Kelemete | #65 | OG | 6” 3″ | 307 | 26 | Washington |
| *Hau’oli KiKaha | #44 | OLB | 6′ 2″ | 253 | 23 | Washington |
| Tim Lelito | #68 | G | 6′ 4″ | 315 | 26 | Grand Valley St |
| Keenan Lewis | #28 | CB | 6′ 1″ | 207 | 29 | Oregon St |
| Micheal Mauti | #56 | LB | 6′ 2″ | 243 | 25 | Penn State |
| Luke McCown | #7 | qB | 6″ 4″ | 217 | 34 | Louisana Tech |
| Mike McGlynn | #63 | G | 6′ 5″ | 309 | 30 | Pittsburgh |
| Thomas Morstead | #6 | P | 6′ 4″ | 225 | 29 | Southern Methodist |
| *Marcus Murphy | #23 | RB/KR | 5′ 8″ | 188 | 23 | Missouri |
| Toben Opurum | #45 | RB | 6′ 1″ | 250 | 24 | Kansas |
| Chris Owens | #30 | DB | 5′ 10″ | 182 | 24 | San Jose State |
| *Andrus Peat | #75 | T | 6′ 7″ | 312 | 21 | Stanford |
| *Bobby Richardson | #78 | DT | 6′ 3″ | 288 | 22 | Indiana |
| Khiry Robinson | #29 | RB | 6′ 0″ | 220 | 25 | West Texas A&M |
| Jamarca Sanford | #38 | FS | 5′ 10″ | 200 | 30 | Mississippi |
| Ryan Seymour | #66 | G | 6′ 4″ | 305 | 25 | Vanderbilt |
| Willie Snead | #83 | WR | 5′ 11″ | 195 | 22 | Ball State |
| CJ Spiller | #28 | RB | 5′ 11″ | 194 | 28 | Clemson |
| Zach Strief | #64 | T | 6′ 7″ | 320 | 33 | Northwestern |
| Vinnie Sunseri | #43 | SS | 5′ 11 | 210 | 22 | Alabama |
| *Damian Swann | #27 | CB | 6′ 0″ | 180 | 22 | Georgia |
| *Jack Tabb | #80 | TE | 6′ 3″ | 250 | 23 | North Carolina |
| *Davis Tull | #55 | OLB | 6′ 2″ | 246 | 23 | Tenn-Chattanooga |
| Max Unger | #60 | C | 6′ 4″ | 299 | 29 | Oregon |
| Kenny Vaccaro | #32 | S | 6′ 0″ | 214 | 24 | Texas |
| Lawerence Virgil | #96 | NT | 6′ 5″ | 290 | 24 | Valdosta State |
| Ben Watson | #82 | TE | 6′ 3″ | 255 | 34 | Georgia |
| Kevin Williams | #93 | DT | 6′ 5″ | 311 | 35 | Oklahoma State |
| *PJ Williams | #36 | CB | 6′ 0″ | 196 | 22 | Florida State |
| Kyle Wilson | #24 | DB | 5′ 10″ | 190 | 28 | Boise State |
- * – Rookie
- + – Pro Bowl Selection
