| Player | # | Pos | Ht | Wt | Age | College |
|---|---|---|---|---|---|---|
| Kikio Alonso | #47 | LB | 6′ 3″ | 239 | 29 | Oregon |
| Stephone Anthony | #55 | LB | 6′ 3″ | 245 | 27 | Clemson |
| Alex Anzalone | #47 | LB | 6′ 3″ | 241 | 25 | Florida |
| Eli Apple | #24 | LCB | 6′ 1″ | 203 | 24 | Ohio State |
| Terron Armistead+ | #72 | LT | 6′ 5″ | 304 | 28 | Arkansas-Pine Bluff |
| Ray Ray Armstrong | #50 | LB | 6′ 3″ | 220 | 28 | Miami (FLA) |
| Dan Arnold | #85 | TE | 6′ 6″ | 220 | 24 | Wisconsin-Platteville |
| Johnson Bademosi | #24 | DB | 6′ 0″ | 219 | 29 | Stanford |
| Vonn Bell | #48 | SS | 5′ 11″ | 205 | 25 | Ohio State |
| Vince Biegel | #59 | LB | 6′ 3″ | 246 | 24 | Wisonsin |
| Drew Brees+ | #9 | QB | 6′ 0″ | 209 | 40 | Purdue |
| Teddy Bridgewater | #5 | QB | 6′ 2″ | 215 | 27 | Louisville |
| Malcolm Brown | #90 | RDT | 6′ 3″ | 320 | 35 | Texas |
| Austin Carr | #80 | WR | 6′ 1″ | 195 | 26 | Northwestern |
| Will Clapp | #64 | G | 6′ 5″ | 311 | 24 | LSU |
| Jared Cook+ | #87 | TE | 6′ 5″ | 254 | 32 | Soth Carolina |
| Ken Crawley | #46 | CB | 6′ 1″ | 180 | 26 | Colorado |
| Marcus Davenport | #92 | DE | 6′ 6″ | 265 | 23 | Texas-San Antonio |
| Demario Davis+ | #56 | LB | 6′ 2″ | 248 | 29 | Arkansas |
| Nick Easton | #62 | C | 6′ 3″ | 303 | 27 | Harvard |
| Mario Edwards | #97 | DE | 6′ 3″ | 280 | 25 | Florida State |
| *Kaden Elliss | #55 | LB | 6′ 3″ | 240 | 24 | Idaho |
| *Chauncy Gardener-Johnson | #22 | DB | 5′ 11″ | 201 | 22 | Florida |
| Ted Ginn | #19 | WR | 5′ 11″ | 180 | 34 | Ohio State |
| *Carl Granderson | #57 | DE | 6′ 5″ | 261 | 23 | Wyoming |
| J.T. Gray | #48 | DB | 6′ 0″ | 202 | 23 | Mississippi State |
| T.J. Green | #32 | FS | 6′ 3″ | 215 | 23 | Clemson |
| *Saquan Hampton | #33 | S | 6′ 1″ | 206 | 24 | Rutgers |
| Justin Hardee | #34 | DB | 6′ 1″ | 200 | 25 | Illinois |
| *Deonte Harris+ | #11 | WR/KR | 5′ 6″ | 170 | 22 | Assumption |
| Trey Hickerson | #91 | DE | 6′ 4″ | 270 | 25 | Florida Atlantic |
| Josh Hill | #89 | TE | 6′ 5″ | 229 | 29 | Idaho St |
| Taysom Hill | #7 | QB/WR/RB/TE | 6′ 2″ | 221 | 29 | BYU |
| Krishawn Hogan | #81 | WR | 6′ 3″ | 217 | 24 | Marian |
| *Lil’Jordan Humphrey | #84 | WR | 6′ 4″ | 225 | 21 | Texas |
| Janoris Jenkins | #20 | DB | 5′ 10″ | 190 | 31 | Florida |
| Cameron Jordan+ | #94 | DE | 6′ 3″ | 287 | 30 | California |
| Alvin Kamara+ | #41 | RB | 5′ 9″ | 215 | 24 | Tennessee |
| Keith Kirkwood | #18 | WR | 6′ 3″ | 210 | 26 | Temple |
| A.J. Klein | #53 | MLB | 6′ 1″ | 240 | 28 | Iowa State |
| Marshon Lattimore+ | #23 | RCB | 6′ 0″ | 192 | 23 | Ohio State |
| Zach Line | #42 | FB | 6′ 1″ | 233 | 29 | SMU |
| Mitchell Loewen | #70 | DE | 6′ 5″ | 285 | 25 | Arkansas |
| Will Lutz | #3 | K | 5′ 11″ | 184 | 25 | Georgia State |
| *Erik McCoy | #78 | C | 6′ “ | 314 | 22 | Texas A&M |
| Thomas Morstead | #6 | P | 6′ 4″ | 225 | 33 | Southern Methodist University |
| Latavius Murray | #28 | RB | 6′ 3″ | 235 | 29 | Central Florida |
| Michael Ola | #65 | T | 6′ 5″ | 312 | 31 | Hampton |
| Patrick Omanameh | #60 | G | 6′ 4″ | 327 | 30 | Michigan |
| David Onyemata | #93 | DE | 6′ 4″ | 300 | 27 | Manitoba |
| Ricky Ortiz | #30 | FB | 6′ 0″ | 233 | 25 | Oregon State |
| Andrus Peat+ | #75 | LG | 6′ 7″ | 312 | 26 | Stanford |
| Ryan Ramczyk★ | #71 | RT | 6′ 6″ | 314 | 25 | Wisconsin |
| Sheldon Rankins | #98 | DT | 6′ 2″ | 305 | 25 | Louisville |
| Craig Robertson | #52 | LB | 6′ 1″ | 234 | 31 | North Texas |
| Patrick Robinson | #21 | RCB | 5′ 11″ | 191 | 32 | Florida State |
| Tre’Quan Smith | #10 | WR | 6′ 2″ | 210 | 23 | Central Florida |
| Taylor Stallworth | #76 | DT | 6′ 2″ | 302 | 24 | South Carolina |
| DJ Swearinger | #21 | DB | 5′ 10″ | 205 | 28 | South Caroina |
| Manti Te’o | #51 | MLB | 6′ 1″ | 241 | 28 | Notre Dame |
| Michael Thomas+★ | #13 | WR | 6′ 3″ | 212 | 26 | Ohio State |
| *Shy Tuttle | #74 | DT | 6′ 3″ | 300 | 24 | Tennessee |
| Jason Vander Laan | #84 | TE | 6′ 3″ | 245 | 27 | Ferris State |
| Larry Warford+ | #67 | RG | 6′ 3″ | 317 | 28 | Kentucky |
| Dwayne Washington | #27 | RB | 6′ 1″ | 223 | 25 | Washington |
| Marcus Williams | #43 | FS | 6′ 1″ | 195 | 23 | Utah |
| PJ Williams | #26 | DB | 6′ 0″ | 196 | 26 | Florida State |
| Zach Wood | #49 | FB | 6′ 3″ | 255 | 26 | SMU |
| Zach Zenner | #34 | RB | 5′ 11″ | 224 | 28 | South Dakota State |
- * – Rookie
- + – Pro Bowl Selection
- ★- All-Pro Selection