| Player | # | Pos | Ht | Wt | Age | College |
|---|---|---|---|---|---|---|
| Alex Anzalone | #47 | MLB | 6′ 3″ | 241 | 24 | Florida |
| Eli Apple | #24 | LCB | 6′ 1″ | 203 | 23 | Ohio State |
| Terron Armistead+ | #72 | T | 6′ 5″ | 304 | 27 | Arkansas-Pine Bluff |
| *Dan Arnold | #85 | TE | 6′ 6″ | 220 | 23 | Wisconsin-Platteville |
| Chris Banjo | #37 | S | 5′ 10″ | 207 | 28 | SMU |
| Vonn Bell | #48 | SS | 5′ 11″ | 205 | 24 | Ohio State |
| Vince Biegel | #59 | LB | 6′ 3″ | 246 | 24 | Wisonsin |
| Drew Brees+ | #9 | QB | 6′ 0″ | 209 | 39 | Purdue |
| Teddy Bridgewater | #5 | QB | 6′ 2″ | 215 | 26 | Louisville |
| Jay Bromley | #90 | DT | 6′ 3″ | 314 | 26 | Syracuse |
| Jerome Bushrod | #74 | T | 6′ 5″ | 318 | 34 | Towson |
| Austin Carr | #80 | WR | 6′ 1″ | 195 | 25 | Northwestern |
| *Will Clapp | #64 | G | 6′ 5″ | 311 | 23 | LSU |
| Kurt Coleman | #20 | SS | 5′ 11″ | 208 | 30 | Ohio State |
| Ken Crawley | #46 | CB | 6′ 1″ | 180 | 25 | Colorado |
| *Marcus Davenport | #92 | DE | 6′ 6″ | 265 | 22 | Texas-San Antonio |
| Demario Davis | #56 | LB | 6′ 2″ | 248 | 29 | Arkansas |
| Tyeler Davison | #95 | RDT | 6′ 2″ | 315 | 26 | Fresno State |
| Mike Gillislee | #25 | RB | 5′ 11″ | 210 | 28 | Florida |
| Ted Ginn | #19 | WR | 5′ 11″ | 180 | 33 | Ohio State |
| *J.T. Gray | #48 | DB | 6′ 0″ | 202 | 22 | Mississippi State |
| Justin Hardee | #34 | DB | 6′ 1″ | 200 | 24 | Illinois |
| Trey Hickerson | #91 | DE | 6′ 4″ | 270 | 24 | Florida Atlantic |
| Josh Hill | #89 | TE | 6′ 5″ | 229 | 28 | Idaho St |
| Taysom Hill | #7 | QB/WR/RB/TE | 6′ 2″ | 221 | 28 | BYU |
| Mark Ingram | #28 | RB | 5′ 9″ | 215 | 29 | Alabama |
| Cameron Jordan+ | #94 | DE | 6′ 3″ | 287 | 29 | California |
| Alvin Kamara+ | #41 | RB | 5′ 9″ | 215 | 23 | Tennessee |
| *Keith Kirkwood | #18 | WR | 6′ 3″ | 210 | 25 | Temple |
| A.J. Klein | #53 | MLB | 6′ 1″ | 240 | 27 | Iowa State |
| Marshon Lattimore | #23 | RCB | 6′ 0″ | 192 | 22 | Ohio State |
| Josh LeRibeus | #61 | OG | 6′ 2″ | 315 | 29 | SMU |
| Tommy Lee Lewis | #87 | WR/KR | 5′ 7″ | 168 | 26 | Northern Illinois |
| Zach Line | #42 | FB | 6′ 1″ | 233 | 28 | SMU |
| Mitchell Loewen | #70 | DE | 6′ 5″ | 285 | 25 | Arkansas |
| Cornelius Lucas | T | 6′ 8″ | 327 | 27 | Kansas State | |
| Will Lutz | #3 | K | 5′ 11″ | 184 | 24 | Georgia State |
| Arthur Maulet | #37 | CB | 5′ 10″ | 190 | 25 | Memphis |
| Cameron Meredith | #81 | WR | 6′ 3″ | 207 | 26 | Illinois State |
| Thomas Morstead | #6 | P | 6′ 4″ | 225 | 32 | Southern Methodist University |
| Derek Newton | #77 | T | 6′ 6″ | 315 | 31 | Arkansas State |
| Alex Okafor | #57 | DE | 6′ 4″ | 261 | 27 | Texas |
| Michael Ola | #65 | T | 6′ 5″ | 312 | 30 | Hampton |
| David Onyemata | #93 | DE | 6′ 4″ | 300 | 26 | Manitoba |
| David Parry | #58 | NT | 6′ 2″ | 317 | 25 | Stanford |
| Andrus Peat+ | #75 | LG | 6′ 7″ | 312 | 25 | Stanford |
| Ryan Ramczyk | #71 | RT | 6′ 6″ | 314 | 24 | Wisconsin |
| Sheldon Rankins | #98 | LDT | 6′ 2″ | 305 | 24 | Louisville |
| Craig Robertson | #52 | LB | 6′ 1″ | 229 | 30 | North Texas |
| Josh Robinson | #32 | WR | 5′ 10″ | 200 | 27 | Central Florida |
| Patrick Robinson | #21 | RCB | 5′ 11″ | 191 | 31 | Florida State |
| *Tre’Quan Smith | #10 | WR | 6′ 2″ | 210 | 22 | Central Florida |
| *Taylor Stallworth | #76 | DT | 6′ 2″ | 302 | 23 | South Carolina |
| Brandon Tate | #15 | WR | 6′ 1″ | 195 | 31 | North Caroina |
| Manti Te’o | #51 | MLB | 6′ 1″ | 241 | 27 | Notre Dame |
| Michael Thomas+★ | #13 | WR | 6′ 3″ | 212 | 25 | Ohio State |
| *Cameron Tom | #63 | G | 6′ 4″ | 300 | 23 | Southren Miss |
| Max Unger+ | #60 | C | 6′ 5″ | 305 | 32 | Oregon |
| Larry Warford+ | #67 | RG | 6′ 3″ | 317 | 27 | Kentucky |
| Dwayne Washington | #27 | RB | 6′ 1″ | 223 | 24 | Washington |
| Marcus Williams | #43 | FS | 6′ 1″ | 195 | 22 | Utah |
| Ben Watson | #82 | TE | 6′ 3″ | 255 | 38 | Georgia |
| Jonathan Williams | #27 | RB | 6′ 0″ | 214 | 24 | Arkansas |
| PJ Williams | #26 | LCB | 6′ 0″ | 196 | 25 | Florida State |
| Zach Wood | #49 | FB | 6′ 3″ | 255 | 25 | SMU |
- * – Rookie
- + – Pro Bowl Selection
- ★- All-Pro Selectione5