| Player | Intercepted | Years |
|---|---|---|
| Drew Brees | 190 | 2006-2020 |
| Archie Manning | 156 | 1971-1982 |
| Aaron Brooks | 84 | 2000-2005 |
| Bobby Hebert | 75 | 1985-1992 |
| Billy Kilmer | 52 | 1967-1971 |
| Dave Wilson | 55 | 1981-1987 |
| Jim Everett | 48 | 1994-1996 |
| Kenny Stabler | 33 | 1982-1985 |
| Bobby Scott | 28 | 1973-1982 |
| Richard Todd | 23 | 1984-1985 |
| Steve Walsh | 22 | 1988-1991 |