| Player | Intercepted | Year |
|---|---|---|
| Drew Brees | 22 | 2010 |
| Aaron Brooks | 22 | 2001 |
| Archie Manning | 22 | 1972 |
| Archie Manning | 20 | 1979 |
| Archie Manning | 20 | 1980 |
| Archie Manning | 20 | 1975 |
| Richard Todd | 19 | 1984 |
| Drew Brees | 19 | 2012 |
| Drew Brees | 18 | 2007 |
| Jim Everett | 18 | 1994 |
| Ken Stabler | 18 | 1983 |
| Drew Brees | 17 | 2008 |
| Aaron Brooks | 17 | 2005 |
| Billy Kilmer | 17 | 1970 |
| Billy Kilmer | 17 | 1968 |
| Billy Kilmer | 17 | 1969 |
| Drew Brees | 17 | 2014 |
| Dave Wilson | 17 | 1986 |
-
Jim Everett -
Dave Wilson
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